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Mechanizm działania polega na zwiększeniu powinowactwa neuroprzekaźnika hamującego, jakim jest kwas γ-aminomasłowy do receptora GABA-A. Dawkowanie: standardowo stosuje się dawki 2–10 mg (przy podaniu doustnym). Aktywne metabolity: nordazepam, oksazepam, temazepam. Ulega rozkładowi w wątrobie – okres półtrwania wynosi 20–100 godzin.
• The active ingredient is diazepam 2 mg, 5 mg, or 10 mg. • The other ingredients are lactose monohydrate, powdered cellulose, maize starch and magnesium stearate (E572). The 5 mg tablet also contains the colours quinoline yellow (E104) and sunset yellow (E110). The 10 mg tablet contains the colour indigo carmine (E132).
Oral and Rectal forms: If you miss a dose of Diazepam 5 MG Tablet, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
A typical adult dose of Valium to treat alcohol withdrawal may be 10 mg three to four times a day for 24 hours followed by 5 mg taken three to four times a day as needed.
Blood or plasma diazepam concentrations are usually in a range of 0.1–1.0 mg/l in persons receiving the drug therapeutically, 1–5 mg/l in those arrested for impaired driving, and 2–20 mg/l in victims of acute overdose.
0.5 mg/kg rectally (using parenteral solution), THEN 0.25 mg/kg in 10 minutes as needed . Pediatric: Potentially toxic dose in patients under 6 years: greater than 0.5 mg/kg . Rectally. ... Diazepam has moderate interactions with at least 238 different drugs.
Diazepam oral tablet is available as both a generic and brand-name drug. ... you shouldn’t take diazepam. Myasthenia gravis is a disease that causes extreme muscle weakness and tiredness.
For muscle spasms, the recommended dose is 2 mg to 10 mg, taken three or four times daily. The recommended Valium dose for controlling seizures is 2 mg to 10 mg, taken two to four times daily. Valium is intended to be used along with other seizure medications.